The MAPK10 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to JNK3, and MAPK10. This antibody recognizes Human, Mouse, and Rat antigen. The MAPK10 Antibody has been validated for the following applications: Western Blot.
Description
Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the beta-amyloid precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons.Mohit A.A., Neuron 14:67-78(1995).Lisnock J., Biochemistry 39:3141-3148(2000).Jagadish N., Biochem. J. 389:73-82(2005)